Mr. Cheng-long Stephan,
PharmD, PhD candidate

2 janvier 2016

02 35 52 00 00
cheng-long.stephan@univ-rouen.fr

Laboratoire SMS
Place Emile Blondel
76821 Mont-Saint-Aignan CEDEX
France

PhD Thesis

Mechanism of stabilisation of metastable polymorphs of active ingredients in the presence of additives.

Education

2019 : Common year of Health Study, University of Reims (France), Valedictorian

2023 : MSc in biotechnology and biomanufacturing, University of Reims (France).

2024 : Doctor of Pharmacy (thesis titled : development and properties of pharmaceutical tablets according to their shape), Univeristy of Reims (France); MSc in pharmaceutical technology, University of Lille (France).

2025 : PhD candidate, SMS laboratory, University of Rouen (France).

Work Experience

2022 : Research internship, GIP CYROI / ICMR Reims, Chemical Profiling of Honey from La Réunion island: a combined approach using Nuclear Magnetic Resonance and Mass Spectrometry, 2 months.  

2023 : Intern in Pharmaceutical technology, University hospital of Reims, 6 months ; Solid oral dosage form development trainee, Delpharm Development Reims, 6 months.

2024 : Biopharmacy and small molecules formulation apprentice, Sanofi Research and Development, 12 months.

2025 : PhD candidate, Mechanism of stabilisation of metastable polymorphs of active ingredients in the presence of additives, ongoing (3 years expected).

 

Papers

I B. Rietveld, C-L. Stephan, G. Gbabode, Navigating phase behaviour in pharmaceuticals to enable phases with desired properties, CrystEngComm (under review).

Awards

Crystal 11 congress, best photo award, 2025.

Symposium Participation

2023 : APGI Info day Poorly soluble drugs: An industrial perpective on formulations for bio-availability enhancement, Paris (France)

2024 : 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Vienna (Austria).

2025 : 1st ADCR Congress, Rouen (France); Crystal 11 congress on industrial cristallization and precipitaiton, Marseille (France).

Scientific Skills
Thermal Analysis (DSC – TG-DSC) – Interpretation
XRay Powder diffraction - user
Microscopy (optical, electronic)
Solution Crystallization (polymorphism control, crystal engineering, salt, co-crystals)
Particle Size Distribution evaluation (Malvern PSD)
Spectroscopy (Raman, Infra-rouge, UV-vis, fluorescence)
Spray drying
Thin films (drop casting, spin-coating)
Solid-state characterization (polymorphism, solvates, cocrystals, solid-solid transition)
Industrial Crystallization Fundamentals