Ms Laureline MARC
PhD Student (Year 3)


02 35 14 63 50

Laboratoire SMS
Place Emile Blondel
76821 Mont-Saint-Aignan CEDEX


PhD Thesis

Continuous Crystallization - Development of new technologies for continuous crystallization of organic molecules intended for the field of fine chemistry

Supervised by Pr. G. Coquerel (SMS) and Dr. J.-M. Schneider (Seqens Porcheville)

CIFRE funding with SEQENS company

Date of defense previsional : 2022

  • 2017-2018 Master’s Degree in Chemistry specialised in Crystallization, Rouen Normandy University, France
  • 2014-2017 « Ingénieur Chimiste » Diploma (equivalent to a top Master’s Degree in Chemistry), ENSCM-Ecole Nationale Supérieure de Chimie de Montpellier (National Graduate School of Chemistry of Montpellier), France
    • Erasmus exchange program (09/2016 – 02/2017) in a Master’s Degree training in Chemical Engineering, Universidad Complutense de Madrid, Spain
  • 2012-2014 DUT Chimie (Technological Degree in Chemistry), IUT Chimie de Grenoble (University Institute of Technology of Chemistry of Grenoble), France
Work Experience
  • 2018-2019 Crystallization Scientist, Crystallization and Solid State Unit, Seqens, Porcheville, France
  • 2014-2017 R&D Chemist in apprenticeship, Sanofi
    • Physical Quality Laboratory, Montpellier, France (2016-2017)
    • Pre-Development Laboratory, Waltham, MA, USA (2016)
    • Process Safety Laboratory, Montpellier, France (2014-2015)
  • 2013-2014 Laboratory Technician in apprenticeship, Chemical Analysis and Characterization Laboratory, Constellium, Voreppe, France

Marc, L.; Guillemer, S.; Schneider, J.-M.; Coquerel, G. Continuous chiral resolution of racemic Ibuprofen by diastereomeric salt formation in a Couette-Taylor crystallizer. Chemical Engineering Research and Design 2022, 178, 95-110.

Marc, L.; Lopes, C.; Schneider, J.-M.; Sanselme, M.; Coquerel, G. Impact of a Partial Solid Solution and Water Molecules on the Formation of Fibrous Crystals and Fluid Inclusions. Crystals 2021, 11, 1188.

Symposium Participation
  • Oral Presentation :

Laureline Marc, Jean-Marie Schneider, Morgane Sanselme and Gérard Coquerel, "Role of water molecules in the formation of fibrous crystals and fluid inclusions of an organic salt", e-CROFI 2021, June 28th to July 2nd 2021, online event ⟨hal-03359374⟩

  • Poster Presentations :

Laureline Marc, Jean-Marie Schneider and Gérard Coquerel, "Continuous chiral resolution by diastereomeric salt formation of racemic Ibuprofen in a Couette-Taylor crystallizer", Journées Nationales Réseau Cristech (CNRS), October 14-16th  2020, Ecully (69), France ⟨hal-03359382⟩

Laureline Marc, Sabrina Guillemer, Jean-Marie Schneider and Gérard Coquerel, "Continuous chiral resolution by diastereomeric salt formation of racemic Ibuprofen in a Couette-Taylor crystallizer", ISIC 21, August 30th to September 2nd 2021, online event ⟨hal-03359396⟩

Laureline Marc, Chrystal Lopes, Jean-Marie Schneider, Morgane Sanselme, Gérard Coquerel, "Chiral purity limitation: discovery of a partial solid solution", Chirafun, November 15-16th 2021, Rennes (35), France ⟨hal-03455543⟩

Scientific Skills
Thermal Analysis (DSC – TG-DSC) – Implementation
Thermal Analysis (DSC – TG-DSC) – Interpretation
XRay Powder diffraction - user
Phase Diagram - Experimental Determination
Microscopy (optical, electronic)
Chiral Resolution by Crystallization
Development of Experimental Prototypes (préciser)
Solution Crystallization (polymorphism control, crystal engineering, salt, co-crystals)
Particle Size Distribution evaluation (Malvern PSD)
Solid-vapour equilibria (DVS)
Solid-state characterization (polymorphism, solvates, cocrystals, solid-solid transition)