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Mr. nicolas Couvrat 42 y.o. +33 (0)2 35 14 70 29 |
Laboratoire SMS |
2019: HDR (Accreditation to supervise research), University of Rouen-Normandy "Contribution à l’étude du désordre structurel dans les matériaux moléculaires : impact de la stéréoisomérie"
2011: European PhD Thesis ““Four case studies on the impact of the heterogeneous equilibria on physicochemical behaviours of organic solids”,
Supervisor: Prof. Gerard Coquerel
2007 :French Master in Material Science, University of Rouen
Research Engineer involved in several industrial partnerships
Operational Manager and expert for Crystallization part in Insitut Carnot I2C (since 2017)
Teaching (ATER /monitor/Temporary replacement: Inorganic Chemistry, Chemistry of Materials and Heterogeneous Equilibria)
N. Patry, N. Hébert, V. Peulon-Agasse, A. Lassin, L. Andre, N. Couvrat, Y. Cartigny, “Experimental determination of CoSO4-Li2SO4-H2O ternary phase diagram between 283.15K and 323.15K”, Journal of Chemical & Engineering Data, 2025, accepted.
B. Atawa, N. Couvrat, F. Affouard, N.T. Correia, G. Coquerel, A. Saiter-Fourcin, “Effects of hydrostatic pressure on amorphous chiral materials: Impact on homochiral or heterochiral H-bond sequences”, Journal of Non-Crystalline Solids, 2024, 640, 123111.
C. J. J. Gérard, C. Pinètre, H. Cercel, M. D. Charpentier, M. Sanselme, N. Couvrat, C. Brandel, Y. Cartigny, V. Dupray, J.H. ter Horst, “Phase diagrams of Praziquantel and Vanillic acid cocrystals: racemic compound and conglomerate system”, Crystal Growth & Design, 2024, 24(8), 3378–3387.
C. Pinètre, L. Harfouche, C. Brandel, E-E. Bendeif, M. Sanselme, Y. Cartigny, N. Couvrat, V. Dupray, “Investigation of the Binary System of Proxyphylline Enantiomers: Structural Resolution and Phase Diagram Determination”, Molecular Pharmaceutics, 2024, 21(2), 845–853.
S. Marais, Q. Lozay, N. Follain, J. Soulestin, N. Couvrat, E. Dargent, “Multinanolayered PA6/Cloisite and PE/PA6/Cloisite composites: structure, mechanical and barrier properties”, Composites Part B: Engineering, 2024, 271, 111167.
G, Baaklini, M. Schindler, L. Yuan, C. De Saint Jores, M. Sanselme , N. Couvrat, S. Clevers, P. Négrier, D. Mondieig, V. Dupray, Y. Cartigny , G. Gbabode, G. Coquerel, “Critical influence of water on the polymorphism of 1,3-dimethylurea and other heterogeneous equilibria”, Molecules, 2023, 28,7061.
F. Simon, N. Couvrat, C. Bilot, S. Marinel, S. Malo, G. Coquerel, “The Solid Solution between NaClO3 and NaBrO3 Revisited”, Minerals, 2023, 13(8), 1006.
A. Lemercier, N. Couvrat, M. Sanselme, Y. Cartigny, Y. Corvis, G. Coquerel, P. Espeau, “Evidence of a New Crystalline Phase of Prednisolone Obtained from the Study of the Hydration–Dehydration Mechanisms of the Sesquihydrate”, Pharmaceutics, 2023, 15(6), 1694.
C. Tizaoui, H. Galai, S. Clevers, N. Couvrat, G. Coquerel, I.B. Rietveld, “The persistence and crystallization behavior of atorvastatin calcium amorphous dispersions in polyvinylpyrrolidone”, Journal of Drug Delivery Science and Technology, 2022, 72, 103375.
B. Atawa, N. Couvrat, F. Affouard, N.T. Correia, G. Coquerel, A. Saiter-Fourcin, “Impact of chirality in the amorphous state of conglomerate forming system: case study of N-acetyl-α-methylbenzylamine”, Physical Chemistry Chemical Physics, 2021, 23, pp 24282-24293.
N. Couvrat, M. Sanselme, M. Poupard, C. Bensakoun, S. H. Drouin, J-M. Schneider, G. Coquerel, “Solid-State Overview of R-Baclofen: Relative Stability of Forms A, B and C and Characterization of a New Heterosolvate”, Journal of Pharmaceutical Sciences, 2021, 110 (10), pp 3465-3471
L. Harfouche, N. Couvrat, M. Sanselme, C. Brandel, Y. Cartigny, G. Coquerel, S. Petit, “Discovering of New Proxyphylline Chiral Cocrystals: Solid State and Dehydration Mechanism”, Crystal Growth and Design, 2020, 20(6), 3842-3850.
C. Tizaoui, H. Galai, M. Barrio, S. Clevers, N. Couvrat, V. Dupray, G. Coquerel, J-L. Tamarit, I.B. Rietveld, “Does the trihydrate of Atorvastatin Calcium possess a melting point ?”, European Journal of Pharmaceutical Sciences, 2020, 148, 105334.
A. Mbodji, G. Gbabode, M. Sanselme, Y. Cartigny, N. Couvrat, M. Leeman, V. Dupray, R.M. Kellogg, G. Coquerel, “Evidence of Conglomerate with Partial Solid Solutions in Ethylammonium Chlocyphos”, Crystal Growth and Design, 2020, 20(4), 2562-2569.
A. Mbodji, G. Gbabode, M. Sanselme, Y. Cartigny, N. Couvrat, M. Leeman, V. Dupray, R.M. Kellogg, G. Coquerel, “Family of Conglomerate-Forming Systems Composed of Chlocyphos and Alkyl-amine. Assessment of Their Resolution Performances by Using Various Modes of Preferential Crystallization”, Crystal Growth & Design, 2019, 19(9), 5173-5183.
M. Schindler, N. Couvrat, Y. Cartigny, C. Brandel, G. Coquerel, “Synthesis and Characterization of sodium dithionate and its dihydrate”, Chemical Engineering and Technology, 2019, 42 (7), 1446-1451.
L. Yuan, E. Horosanskaia, F. Engelhardt, F. T. Edelmann, N. Couvrat, Y. Cartigny, G. Coquerel, A. Seidel-Morgenstern, H. Lorenz, “Solvate formation of bisdemethoxycurcumin: Crystal structure analyses and stability investigations ”, Crystal Growth and Design, 2019, 19(2), 854–867.
B. Atawa, N. Couvrat, F. Affouard, N.T. Correia, G. Coquerel, E. Dargent, A. Saiter, “Molecular Mobility of Amorphous N-Acetyl-α-Methylbenzylamine and Debye Relaxation evidenced by Dielectric Relaxation Spectroscopy and Molecular Dynamic Simulations”, Physical Chemistry Chemical Physics, 2019, 21, 702-707.
N. Couvrat, M. Sanselme, Y. Cartigny, F. De Smet, S. Rome, L. Aerts, L. Quéré, J. Wouters, G. Coquerel, "A Possible Infinite Number of Components in a Single Crystalline Phase: On the Isomorphism of Brivaracetam–Guest Molecules", Crystal Growth and Design, 2018, 18 (9), pp 4807–4810.
B.Atawa, N.Couvrat, G.Coquerel, E.Dargent, A.Saiter, "Chirality impact on physical ageing: a new and original case of a small organic molecule", Material Letters, 2018, 228, pp 141–144.
B. Schammé, N. Couvrat, V. Tognetti, L. Delbreilh, V. Dupray, E. Dargent et G. Coquerel, "Investigation of Drug–Excipient Interactions in Biclotymol Amorphous Solid Dispersions", Molecular Pharmaceutics, 2018, 15(3), pp 1112-1125.
N. Couvrat, J. Mahieux, M. Sanselme, G. Coquerel, "Limitations during the resolution of (±)-Epinephrine by using tartaric acid", Chemical Engineering & Technology, 2018, 41(6), pp 1086-1092.
B. Atawa, N. Couvrat, G. Coquerel, E. Dargent, A. Saiter, "Impact of Chirality on the Glass Forming Ability and the Crystallization from the Amorphous State of 5-ethyl-5-methylhydantoin, a Chiral Poor Glass Former", International Journal of Pharmaceutics, 2018, 540(1-2), pp. 11-21.
B. Schammé, X. Monnier, N. Couvrat, L. Delbreilh, V. Dupray, E. Dargent, G. Coquerel, "Insights on the Physical State Reached by an Active Pharmaceutical Ingredient upon High-Energy Milling", J. Phys. Chem. B, 2017, 121, 5142−5150.
A. Burel, N. Couvrat, S. Tisse, Y. Cartigny, P. Cardinael, G. Coquerel, "Binary phase diagrams between Phenanthrene and two of its impurities: 9,10-dihydroanthracene and Carbazole", Eur. Phys. J. Special Topics, 2017, 226(5), pp 869-880.
N. Couvrat, J. Mahieux, B. Fours, Y. Cartigny, E. Schenkel, L. Aerts, L. Quéré, G. Coquerel, "Impact of sodium chloride on the expansion of a liquid-liquid miscibility gap in an API/water system. Case study of Brivaracetam", Int. J. Pharm., 2016, 515, 702-707.
N. Couvrat, D. Martins, A. Lafontaine, M. Sanselme, V. Dupray, P. Taulelle, J.M. Lerestif, M. Lynch, L. Vaysse-Ludot, G.Coquerel, “Partial Blockage of the reversible solid-solid transition of strontium succinate”,Chem. Eng. Tech, 2016, 39 (7), 1224-1230.
B. Schammé, N. Couvrat, P. Malpeli, E. Dudognon, L. Delbreilh, V. Dupray, E. Dargent, G. Coquerel, “Transformation of an active pharmaceutical ingredient upon high-energy milling: A process-induced disorder in Biclotymol”, Int. J. Pharm., 2016, 499 (1-2), 67-73.
A. Burel, S. Brugman, M. Mignot, Y. Cartigny, S. Tisse, N. Couvrat, P. Cardinael, G. Coquerel, “Phenanthrene purification: comparison of Zone-Melting and Co-Crystallization”, Chem. Eng. Tech, 2016, 39 (7), 1317-1325.
N. Couvrat, Y. Cartigny, J. Linol, L. Vaysse-Ludot, P. Langlois, G.Coquerel, “Crystallization of Terutroban Sodium Salt Hydrate from the Deliquescent State”, Chem. Eng. Tech., 2015, 38 (6), 999-1005.
B. Schammé, N. Couvrat, P. Malpeli , L. Delbreilh, V. Dupray, E. Dargent, G. Coquerel, “Crystallization kinetics and molecular mobility of an amorphous active pharmaceutical ingredient: a case study with Biclotymol”, Int. J. Pharm., 2015, 490 (1–2), 248–257.
C. Brandel, Y. Cartigny, N. Couvrat, M.E. Eusebio, J. Canotilho, S. Petit, G. Coquerel, “Mechanisms of Reversible Phase Transitions in Molecular Crystals: Case of Ciclopirox”, Chem. Mater., 2015, 27 (18), 6360–6373.
N. Couvrat, A. Burel, S. Tisse, Y. Cartigny, G. Coquerel, “Combining zone melting and preparative chromatography to purify Phenanthrene”, J. Therm. Anal. Cal., 2013, 112 (1), 293-300.
A. Waldschmidt, V. Dupray, B. Berton, N. Couvrat, S. Petit, G. Coquerel, “Incidence of crystal growth conditions on the formation of macroscopic liquid inclusions in Ciclopirox crystals”, J. Cryst. Growth, 2012, 342(1), 72-79.
A. Waldschmidt, N. Couvrat, B. Berton, V. Dupray, S. Morin, S. Petit, G. Coquerel, “Impact of gas composition in the mother liquor on the formation of macroscopic inclusions and crystal growth rates. Case study with Ciclopirox crystals”, Cryst. Growth Des., 2011, 11(6), 2463-2470.
N. Couvrat, A-S. Blier, B. Berton, Y. Cartigny, V. Dupray, G. Coquerel, “Characterization of defects inside single crystals of Ciclopirox”, Cryst. Growth Des., 2009, 9(6), 2719-2724.
