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Mr. nicolas Couvrat
Research Engineer

35 y.o.

+33 (0)2 35 14 70 29
nicolas.couvrat@univ-rouen.fr

Laboratoire SMS
Place Emile Blondel
76821 Mont-Saint-Aignan CEDEX
France

 

PhD Thesis

2011: European PhD Thesis ““Four case studies on the impact of the heterogeneous equilibria on physicochemical behaviours of organic solids”,
 Supervisor: Prof. Gerard Coquerel

Education

2007 :French Master in Material Science, University of Rouen

2005: French Bachelor of Science in Health Engineering, University of Rouen

Work Experience

Teaching (ATER /monitor, 224h eq TD mainly in Inorganic Chemistry, Chemistry of Materials and Heterogeneous Equilibria)

Research Engineer involved in several industrial partnerships (Servier, UCB, Inabata-PharmaSynthèse, PCAS, Quantum Genomics, BioProjet, etc.)

Operational Manager for "Formulation" department of Tremplin Carnot I2C (since 2017)

Papers
N. Couvrat, M. Sanselme, Y. Cartigny, F. De Smet, S. Rome, L. Aerts, L. Quéré, J. Wouters, G. Coquerel, "A Possible Infinite Number of Components in a Single Crystalline Phase: On the Isomorphism of Brivaracetam–Guest Molecules", Crystal Growth and Design, 2018, 18 (9), pp 4807–4810.
 
B.Atawa, N.Couvrat, G.Coquerel, E.Dargent, A.Saiter, "Chirality impact on physical ageing: a new and original case of a small organic molecule", Material Letters, 2018, 228, pp 141–144. 
 
B. Schammé, N. Couvrat, V. Tognetti, L. Delbreilh, V. Dupray, E. Dargent et G. Coquerel, "Investigation of Drug–Excipient Interactions in Biclotymol Amorphous Solid Dispersions", Molecular Pharmaceutics, 2018, 15(3), pp 1112-1125.
 
N. Couvrat, J. Mahieux, M. Sanselme, G. Coquerel, "Limitations during the resolution of (±)-Epinephrine by using tartaric acid", Chemical Engineering & Technology, 2018, 41(6), pp 1086-1092.
 
B. Atawa, N. Couvrat, G. Coquerel, E. Dargent, A. Saiter, "Impact of Chirality on the Glass Forming Ability and the Crystallization from the Amorphous State of 5-ethyl-5-methylhydantoin, a Chiral Poor Glass Former", International Journal of Pharmaceutics, 2018, 540(1-2), pp. 11-21.
 
 B. Schammé, X. Monnier, N. Couvrat, L. Delbreilh, V. Dupray, E. Dargent, G. Coquerel, "Insights on the Physical State Reached by an Active Pharmaceutical Ingredient upon High-Energy Milling", J. Phys. Chem. B, 2017, 121, 5142−5150.
 
A. Burel, N. Couvrat, S. Tisse, Y. Cartigny, P. Cardinael, G. Coquerel, "Binary phase diagrams between Phenanthrene and two of its impurities: 9,10-dihydroanthracene and Carbazole", Eur. Phys. J. Special Topics, 2017, 226(5), pp 869-880.
 
N. Couvrat, J. Mahieux, B. Fours, Y. Cartigny, E. Schenkel, L. Aerts, L. Quéré, G. Coquerel, "Impact of sodium chloride on the expansion of a liquid-liquid miscibility gap in an API/water system. Case study of Brivaracetam", Int. J. Pharm., 2016, 515, 702-707.
 
N. Couvrat, D. Martins, A. Lafontaine, M. Sanselme, V. Dupray,  P. Taulelle, J.M. Lerestif, M. Lynch, L. Vaysse-Ludot, G.Coquerel, “Partial Blockage of the reversible solid-solid transition of strontium succinate”,Chem. Eng. Tech, 2016, 39 (7), 1224-1230.
              
B. Schammé, N. Couvrat, P. Malpeli, E. Dudognon, L. Delbreilh, V. Dupray, E. Dargent, G. Coquerel, “Transformation of an active pharmaceutical ingredient upon high-energy milling: A process-induced disorder in Biclotymol”, Int. J. Pharm., 2016, 499 (1-2), 67-73.
 
A. Burel, S. Brugman, M. Mignot, Y. Cartigny, S. Tisse, N. Couvrat, P. Cardinael, G. Coquerel, “Phenanthrene purification: comparison of Zone-Melting and Co-Crystallization”, Chem. Eng. Tech, 2016, 39 (7), 1317-1325.
 
N. Couvrat, Y. Cartigny, J. Linol, L. Vaysse-Ludot, P. Langlois, G.Coquerel, “Crystallization of Terutroban Sodium Salt Hydrate from the Deliquescent State”, Chem. Eng. Tech., 2015, 38 (6), 999-1005.
 
B. Schammé, N. Couvrat, P. Malpeli , L. Delbreilh, V. Dupray, E. Dargent, G. Coquerel, “Crystallization kinetics and molecular mobility of an amorphous active pharmaceutical ingredient: a case study with Biclotymol”, Int. J. Pharm., 2015, 490 (1–2), 248–257.
 
C. Brandel, Y. Cartigny, N. Couvrat, M.E. Eusebio, J. Canotilho, S. Petit, G. Coquerel, “Mechanisms of Reversible Phase Transitions in Molecular Crystals: Case of Ciclopirox”,  Chem. Mater., 2015, 27 (18), 6360–6373.
 
N. Couvrat, A. Burel, S. Tisse, Y. Cartigny,  G. Coquerel, “Combining zone melting and preparative chromatography to purify Phenanthrene”, J. Therm. Anal. Cal., 2013, 112 (1), 293-300.
 
A. Waldschmidt, V. Dupray, B. Berton, N. Couvrat, S. Petit, G. Coquerel, “Incidence of crystal growth conditions on the formation of macroscopic liquid inclusions in Ciclopirox crystals”, J. Cryst. Growth, 2012, 342(1), 72-79.
 
A. Waldschmidt, N. Couvrat, B. Berton, V. Dupray, S. Morin, S. Petit, G. Coquerel, “Impact of gas composition in the mother liquor on the formation of macroscopic inclusions and crystal growth rates. Case study with Ciclopirox crystals”, Cryst. Growth Des., 2011, 11(6), 2463-2470.
 
N. Couvrat, A-S. Blier, B. Berton, Y. Cartigny, V. Dupray, G. Coquerel, “Characterization of defects inside single crystals of Ciclopirox”, Cryst. Growth Des., 2009, 9(6), 2719-2724.
Symposium Participation
Oral : «Phenanthrene purification: comparison between Zone Melting and Co-Crystallization», A. Burel, S. J. T. Brugman, M. Mignot, V. Peulon-Agasse, N. Couvrat, Y. Cartigny, S. Tisse, P. Cardinael, G. Coquerel; JEEP (Days of Phase Equilibria) n°42, 2016, Paris (France).
 
Oral: «Partial Blockage of the reversible solid-solid transition of strontium succinate», N. Couvrat, M. Sanselme, V. Dupray, P. Taulelle, J.M. Lerestif, M. Lynch, L. Vaysse-Ludot, G. Coquerel; BIWIC (Bremen International Workshop for Industrial Crystallization) 2015, Daejon (South Korea).
 
Oral : «A new Zone Melting prototype to purify Phenanthrene», A. Burel, N. Couvrat, S. Tisse, Y. Cartigny, G. Coquerel, JEEP (Days of Phase Equilibria) n°40, 2014, Lyon (France).
 
Oral : «Second Harmonic Generation efficiency in binary eutectic mixtures», F. Simon, S. Clevers, N. Couvrat, V. Dupray, G. Coquerel; JEEP (Days of Phase Equilibria) n°39, 2013, Nancy (France).
 
Oral: «About the formation of liquid inclusions inside organic crystals: How vacuoles give indirect proofs of different crystal growth episodes», N. Couvrat, G. Coquerel; ACTS (Asian Crystallization Technology Symposium) n°1, 2012, Seoul (South Korea).
 
Oral (Plenary Lecture): «Co-crystals and other crystalline molecular complexes: a journey through the solid state chemistry of Brivaracetam», L. Quéré, S. Rome, F. De Smet, S. Le Meur, L. Aerts, J. Wouters, N. Couvrat, G. Coquerel; CGOM (Crystal Growth of Organic Materials) 10, 2012, Limerick (Ireland).
 
Poster: «Purification of polycyclic aromatic hydrocarbons by co-crystallization», A. Burel, S. J. T. Brugman, N. Couvrat, Y. Cartigny, S. Tisse, P. Cardinael, G. Coquerel ; BIWIC (Bremen Industrial Workshop for Industrial Crystallization) 2016, Magdeburg (Germany). 
 
Poster: «Purification of Phenanthrene by Co-Crystallization», A. Burel, S. J. T. Brugman, Y.Cartigny, N. Couvrat, S. Tisse, P. Cardinael, G. Coquerel; 12th International Workshop of the Crystal Growth of Organic Material (CGOM) & 47th Annual British Association of Crystal Growth Conference (BACG) Joint Conference, 2016, Leeds (England).
 
Poster : « Competition between stable and metastable equilibria upon recrystallization from the amorphous state of a chiral molecule», B. Atawa, N. Couvrat, G. Coquerel, E. Dargent, A. Saiter, JEEP (Days of Phase Equilibria) n°42, 2016, Paris (France).
 
Poster: « Influence Of The Water Content On The Solid-solid Transition Of 1,3-dimethylurea», G. Baaklini, M. Schindler, Y. Cartigny, N. Couvrat, M. Sanselme, G. Coquerel; BIWIC (Bremen International Workshop for Industrial Crystallization) 2015, Daejon (South Korea).
 
Poster: « Contribution of Phase Equilibria to Phenanthrene Ultrapurification: Comparison between Zone Melting and Co-Crystallization», A. Burel, S. Brugman, N. Couvrat, S. Tisse, Y. Cartigny, G. Coquerel; BIWIC (Bremen International Workshop for Industrial Crystallization) 2015, Daejon (South Korea).
Scientific Skills
Thermal Analysis (DSC – TG-DSC) – Implementation
Thermal Analysis (DSC – TG-DSC) – Interpretation
XRay Powder diffraction - user
Phase Diagram - Experimental Determination
Heterogeneous Equilibria
Microscopy (optical, electronic)
Development of Experimental Prototypes (préciser)
Solution Crystallization (polymorphism control, crystal engineering, salt, co-crystals)
Spectroscopy (Raman, Infra-rouge, UV-vis, fluorescence)
Amorphous state characterization (thermal analysis / Broadband Dielectric Spectroscopy)
Discontinuous Isoperibolic thermal analysis