Mr. Yohann CARTIGNY
Associate Professor, HDR

 

+33 02 35 52 29 54
yohann.cartigny@univ-rouen.fr

Laboratoire SMS
Place Emile Blondel
76821 Mont-Saint-Aignan CEDEX
France

 

PhD Thesis

PhD in physics and chemistry of matter and materials – University of Lorraine (France 2004): “Lead alloys for acid batteries : i) Thermodynamic study of the PbCaSn system ii) optimization of a new elaboration process by powder metallurgy for electrode grids

Education

2001 : Master Degree in in physics and chemistry of matter and materials – Nancy, University of Lorraine (France)

1999: Bachelor in Physic and Chemistry Sciences Nancy, University of Lorraine (France)

Work Experience
From september 2017 : Headteacher of the Master2 Cristallization - University of Rouen
 
From september 2005 : Associate Professor in Materials Chemistry at the “Sciences et Méthodes Séparatives (SMS)” Laboratory, Rouen Normandie University.
 
Teaching activities  : inorganic chemistry, phase diagram, inorganic materials, general chemistry (University of Rouen (bachelor student) and in school of teaching)
Research activities are focused on the study and the experimental establishment of phase diagrams between organic molecules.
Expertise for Solid-solid (polymorphism, specific transformations), solid-liquid (crystallization processes, solvate formation) and solid-vapor equilibria (solvate formation, salvation mechanisms, stability of organic materials vs partial pressure of solvent, expert in gravimetric vapour sorption).
 
September 2004-august 2005 : Teaching in inorganic chemistry at the University of Nancy (Bachelor, courses, practical studies)
 
September 2001-September 2004 : Teaching given (during the thesis) at University of Metz in "Mineral  chemistry" (192h)
Papers
  • Y. Cartigny, J.M. Fiorani, A. Maître, M. Vilasi, « Thermodynamic assessment on the Pb–Ca–Sn ternary system », Intermetallics, Vol. 11, n° 11-12 (2003) 1205-1210.
  • F. Querniard, J. Linol, Y. Cartigny, G. Coquerel, « Study of the quaternary system (+) and (–)5-phenyl-5-trifluroromethyl-imidazolidine-2,4-dione / (–)1-phenyl-ethylamine/Ethanol  at 20°C under atmospheric pressure”, Journal of thermal analysis and calorimetry; Vol 90 (2007) 359-365.
  • L. Renou, S. Coste, Y. Cartigny, M-N Petit, C. Vincent, J-M Schneider, G. Coquerel , « Mechanism of hydration and dehydration of ciclopirox ethanolamine (1.1) », Crystal Growth and Design, vol 9 (2009) 3918-3927.
  • Y. Amharar, S. Petit, M. Sanselme, Y. Cartigny, M-N Petit, G. Coquerel, “ Crystal Structures, Dehydration Mechanism, and Chiral Discrimination in the Solid State of a Hydantoin Derivative”, Crystal Growth & Design, vol 11 (2011), 2453-2462.
  • A. Lafontaine, M. Sanselme, Y. Cartigny, P. Cardinael, G. Coquerel, Charactherization of the transition between the monohydrate and the anhydrous citric acid, Journal of Thermal Analysis and Calorimetry, vol 112 (2013), 307-315.
  • N. Couvrat, A. Burel, S. Tisse, Y. Cartigny, G. Coquerel, Combining Zone melting and preparative chromatography to purify phenanthrene, Journal of Thermal Analysis and Calorimetry, vol 112 (2013), 293-300.
  • R. Rotival, Y. Corvis, Y. Cartigny, P. Negrier, M. Marchivie, S. Massip, I. Gana, P. Lemoine, P. Espeau, « Comprehensive Determination of the Solid State Stability of Bethanechol Chloride Active Pharmaceutical Ingredient using Combined Analytical Tools” Cryst. Eng. Comm (2013) 15, 7970-7980.
  • C. Brandel, Y. Amharar, Y. Cartigny, S. Petit, G. Coquerel, J. Rollinger, U. Griesser, “Crystallization Behavior of Diprophylline Mixtures of Enantiomers. Preparative Chiral Resolution via Favorable Kinetic whereas Unfavorable Thermodynamic Situation”, Molecular Pharmaceutics (2013), 10(10), 3850-3861.
  • C. Brandel,  G. Gbabode, Y. CARTIGNY, C. Martin, G. Gouhier, S.Petit, G. Coquerel « Crystal Growth, Structure and Polymorphic Behavior of an Ionic Liquid: Phthalate Derivative of N-butyl,N-methylimidazolium Hexafluorophosphate » Chemistry of materials (2014), 26 (14), 4151-4162.
  • B. Fours, Y. Cartigny, S. Petit, G. Coquerel, “Formation of New Polymorphs Without any Nucleation Step : Desolvation of the Rimonabant Monohydrate: Directional Crystallisation Concomitant to Smooth Dehydration”, Faraday discussion (2015), 179, 475-488
  • C. Brandel, Y. Cartigny, N. Couvrat, M. Ermelinda S. Eusebio, J. Canotilho, S. Petit, G. Coquerel, « Mechanisms of Reversible Phase Transitions in Molecular Crystals: Case of Ciclopirox”, Chemistry of materials (2015), 27 (18), 6360-6373
  • C. Neurohr, M. Marchivie, S. Lecomte, Y. Cartigny, N. Couvrat, M. Sanselme, P. Subra-Paternault, « Naproxen–Nicotinamide Cocrystals: Racemic and Conglomerate Structures Generated by CO2 Antisolvent Crystallization, Crystal Growth & Design (2015), 15 (9), 4616-4626
  • A Possible Infinite Number of Components in a Single Crystalline Phase: On the Isomorphism of Brivaracetam–Guest Molecules
    N. Couvrat, M. Sanselme, Y. Cartigny, F. De Smet, S. Rome, L. Aerts, L. Quéré, J. Wouters, G. Coquerel,
    Crystal Growth & Design, 2018, 18(9), pp 4807-4810. DOI: 10.1021/acs.cgd.8b00331

  • Retention modeling and retention time prediction in gas chromatography and flow-modulation comprehensive two-dimensional gas chromatography: The contribution of pressure on solute partition Antoine Burel, Marie Vaccaro, Yohann Cartigny, Séverine Tisse, Gérard Coquerel, Pascal Cardinael, Journal of Chromatography A, 2017, 1485,  pp. 101–119 (DOI: 10.1016/j.chroma.2017.01.011)

  • Binary phase diagrams between Phenanthrene and two of its impurities: 9,10-dihydroanthracene and Carbazole, Antoine Burel, Nicolas Couvrat, Séverine Tisse, Yohann Cartigny, Pascal Cardinael, Gérard Coquerel, Eur. Phys. J. Special Topics, 2017, 226(5), pp 869-880 (DOI: 10.1140/epjst/e2016-60270-0)

  • Crystallization from the Amorphous State of a Pharmaceutical Solid: Impact of Chirality and Chemical Purity, Q. Viel, C. Brandel, Y. Cartigny, M.E. Eusebio, J. Canotilho, V. Dupray, E. Dargent, G. Coquerel, S. Petit Cryst. Growth Des., 2017, 17, 337-346 (DOI 10.1021/acs.cgd.6b01566)

Patent :

N. Couvrat, M.N. Petit, Y. Cartigny, G. Coquerel, F. Balavoine, J. Madec, J.M. Schneider, “Method for the preparation of (3S,3S’) 4,4’-disulfanediylbis(3-aminobutane 1-sulfonic acid)”,WO/2012/045849, PCT/EP2011/067524

Symposium Participation
A. Lafontaine (doctorant encadré), M. Sanselme, Y. Cartigny, P. Cardinael, G. Coquerel, “Characterization of the transition between the monohydrate and the anhydrous citric acid”, Jounées d’Etude des Equilibres entre Phases, Rouen, 28-30 mars 2012.
 
C. Brandel (doctorant encadré), Y. Cartigny, S. Petit, G. Coquerel  , « Investigations in an unusual binary phase diagram between enantiomers: the case of Diprophylline”, Jounées d’Etude des Equilibres entre Phases, Rouen, 28-30 mars 2012.
 
C. Brandel (doctorant encadré), Y. Cartigny, S. Petit and G. Coquerel, “Complex Interactions in the binary System between Enantiomers of Diprophylline”,  12th International conference of pharmacy and Applied physical chemistry, Graz (Austria), 6-9 mai 2012 (Doctorant Co-encadre)
 
C. Brandel (doctorant encadré), Y. Cartigny, S. Petit, G. Gouhier, G. Coquerel, “Crystal Growth Study of an Ionic Liquid: Polymorphism, Oiling Out and Complex Melting Behavior”, 20th International Workshop on Industrial Crystallization (BIWIC2013), Odense, Denmark, 18-20 septembre 2013
 
Antoine Burel (doctorant encadré), N. Couvrat, S. Tisse, Y. Cartigny, G. Coquerel, “A new Zone melting process to purify Phenanthrene”, JEEP 2014, Lyon
 
S. Petit, C. Brandel, J.M. Rollinger, U.J. Griesser, Y. Cartigny, G. Coquerel, “Versatile crystallization behavior of a chiral API : Diprophylline”, CECAM-USI Workshop: Molecular simulations of crystallization from solution, Lugano (CH), Mai 2014, Abstract book, p. 14
 
S. Petit, C. Brandel, A. Waldschmidt, G. Gouhier, Y. Cartigny, G. Coquerel, “About fluid inclusions and morphological transitions in organic and ionic crystals”, ISIC-19 (International Symposium on Industrial Crystallization), Toulouse, Septembre 2014
 
Anais Lafontaine, Y. Cartigny, M. Sanselme, G. Coquerel, « Development of a new X-Ray diffractomer in a reflection mode - for in situ characterization during crystallization processes “ ISIC-19 (International Symposium on Industrial Crystallization), Septembre 2014
 
Y. Cartigny, G. Coquerel, « Contribution of solide/vapor equilibria for the determination ofr phase diagrams between organic molecule and solvent”, 13th Joint European thermodynamic conference, Nancy, 20-22 mai 2015.
 
Quentin VIEL, Clément BRANDEL, Yohann CARTIGNY, Gérard COQUEREL, Eric DARGENT, Samuel PETIT "Molecular Mobility vs Polymorphism of Chiral Pharmaceutical Compounds: Case of Diprophylline",  POLYCHAR23, Lincoln Nebraska USA, 11-15 may 
 

In-situX®: In-situ X-ray for monitoring crystallization in solution, Yohann Cartigny, Gérard Coquerel, Morgane Sanselme & Simon Clevers, Ccongrès Société Française de Génie des procédés, Nancy, Juillet 2017

Etude expérimentale des équilibres solide-liquide du système binaire 1,3 dimethylurée-eau : équilibre métatectique, métastabilité, polymorphisme, hydratation…bienvenue dans le monde des diagrammes de phases de molecules organiques. Manon Schindler, Grace Baaklini, Yohann Cartigny, Nicolas Couvrat, Morgane Sanselme, Clément Brandel and Gérard Coquerel, 1ère journée TEEP (Thermodynamique des équilibres entre phases), Decembre 2017, Clermont-Ferrand

Diagrammes de phases appliqués à la Cristallisation, Yohann CARTIGNY, Journées CRISTECH, Porquerolles, octobre 2018

 
 
Posters
C. Brandel, Y. Cartigny, S. Petit, G. Coquerel, “Versatility of Chiral Discrimination Mechanisms in the Crystal Forms of Diprophylline”, ISIC-19, Toulouse, September 2014
 
N. Couvrat , Y. Cartigny, J. Linol, L. Vaysse-Ludot, P. Langlois, G. Coquerel, “Crystallization of Hydrate(s) from the deliquescent state: On the importance of controlling APIs storage conditions”, BIWIC, Rouen, September 2014
 
Q. Viel, C. Brandel, Y. Cartigny, G. Coquerel, E. Dargent, S. Petit, “Exploring different routes of Crystallization from Amorphous Diprophylline at Racemic and Pure Compositions”, BIWIC, Rouen, September 2014
 
Y. Cartigny,  A. Lafontaine, M. Sanselme, P. Cardinael, G. Coquerel , “ Characterization of the transition between the monohydrate and the anhydrous citric acid », Journées thématiques sur la thermodynamique du solide, Société Française du Génie des Procédés, Paris Décembre 2014
 
A.Lafontaine, M. Sanselme, Y. Cartigny, G. Coquerel , « Development of a new X-Ray diffractomer in a reflexion mode for in situ characterization during crystallization processes”, Journées thématiques sur la thermodynamique du solide, Société Française du Génie des Procédés, Paris Décembre 2014
 
Q. Viel, Y. Cartigny, G. Gbabode, G. Coquerel, J. Canotilho, M.E.S. Eusébio, S. Petit, E. Dargent, "Influence of sample covering on the polymorphic and solid-solid transitions of a chiral molecule: Diprophylline", BIWIC 2015, Korea Deajeon, 9-11 september
 
Q. Viel, Y. Cartigny, G. Coquerel, S. Petit, E. Dargent , "Incidence of confinement in the crystallization route from the amorphous state of a chiral molecule", Mars 2015, 41th JEEP, Coimbra, Portugal
 
A. Burel (doctorant encadré), S. Brugman, N. Couvrat, S. Tisse, Y. Cartigny, G. Coquerel , "Phase Diagrams for optimization of Phenanthrene purification processes: Zone Melting vs. Co-crystallization”, Mars 2015, 41th JEEP, Coimbra, Portugal
 
A. Burel (doctorant encadré), N. Couvrat, S. Tisse, Y. Cartigny, P. Cardinaël, G. Coquerel, « La fusion de zone comme technique séparative appliquée à l’ultrapurification préparative du Phénanthrène », Avril 2015, SEP15, Paris, France
 
A. Burel, S. Brugman, N. Couvrat, S. Tisse, Y. Cartigny, G. Coquerel, “Contribution of Phase Equilibria to Phenanthrene Ultrapurification: Comparison between Zone Melting and Co-Crystallization »  Septembre 2015, BIWIC, Daejon, Corée du Sud
 
G. Baaklini, M. Sanselme,Y. Cartigny, G. Coquerel, “Influence of the water content on the solid-solid transition of 1,3-dimethylurea”, JEEP 2015, Coimbra Portugal , Mars 2015
 
Phenanthrene purification: comparison between zone melting and co-crystallization
A. Burel, S.J.T. Brugman, M. Mignot, V. Peulon-Agasse, N. Couvrat, Y. Cartigny, S. Tisse, P. Cardinael, G. Coquerel
42èmes JEEP (Conference on Phase Equilibria), Univ. Paris Descartes, Mars 2016, Abstract book, p. 33
Metastable eutectic composition determination of 1, 3-dimethylurea/water system by temperature-resolved second harmonic generation (TR-SHG)
L.N. Yuan, S. Clevers, G. Baaklini, N. Couvrat, Y. Cartigny, V. Dupray, G. Coquerel
Asian Crystallization Technology Symposium (ACTS), Tainjin, China, Mai 2016
 

 

Scientific Skills
Thermal Analysis (DSC – TG-DSC) – Implementation
Thermal Analysis (DSC – TG-DSC) – Interpretation
XRay Powder diffraction - user
Phase Diagram - Experimental Determination
Heterogeneous Equilibria
Microscopy (optical, electronic)
Chiral Resolution by Crystallization
Solution Crystallization (polymorphism control, crystal engineering, salt, co-crystals)
Particle Size Distribution evaluation (Malvern PSD)
Solid-vapour equilibria (DVS)
Discontinuous Isoperibolic thermal analysis
BET – surface analysis