Français
English
 |
Lina HARFOUCHE 27 y.o. 06 11 36 40 49 |
Laboratoire SMS |
Ph.D.: Materials Chemistry
Jan. 2017 - May 2020
University of Rouen Normandy – Rouen, France
- Marie Skłodowska-Curie Innovative Training Network Fellow
- Completed professional development in:
- Training and research in the field of chirality, synthesis, and crystallization
- Training on transferable skills: project management, upward communication, intellectual property, public engagement, dissemination of results
EdX, Inc. (online Learning Platform): Business CommunicationAug. 2020 University of British Columbia – Vancouver, Canada |
EdX, Inc. (online Learning Platform): Business FoundationsJun. 2020 University of British Columbia – Vancouver, Canada |
Ph.D.: Materials ChemistryMay 2020 University of Rouen Normandy – Rouen, France |
Master 2: Physical Chemistry, Materials and CatalysisJul. 2016 Lebanese University – Beirut, Lebanon |
Master 1: Environmental ChemistryJul. 2015 Lebanese University – Beirut, Lebanon |
Master 1: Analytical ChemistryJul. 2014 Lebanese University – Beirut, Lebanon |
Bachelor: General ChemistryJul. 2013 Lebanese University – Beirut, Lebanon |
Postdoctoral Researcher
Sept. 2020 – Present
University of Rouen Normandy – Rouen, France
- Crystallization kinetics: studying growth kinetics occurring during crystallization from solution
- Characterization of materials: XRPD, DSC, TGA, Crystal16, SEM, solubility, and induction time
- Probability Distributions of Induction Times
- Usage of vibrational circular dichroism spectroscopy technique
MARIE SKŁODOWSKA-CURIE Fellow
Jan. 2017 – Mar. 2020
University of Rouen Normandy – Rouen, France
- Crystallization of APIs: Screening and evaluation of polymorphs and cocrystals
- Characterization techniques: NMR, XRPD, DSC, TGA, DVS, FTIR, Raman, Crystal16, hot stage and polarized microscopy, SEM, solubility and HPLC
- Optimization of crystallization and chiral resolution processes
- Solid-state landscape study and construction of phase diagrams
- Characterization of solid-solid transition mechanisms and dehydration processes
- Writing scientific articles and reports
- Presentation of results in 9 international conferences, workshops, and summer schools
- Collaboration with foreign institutions: Corbion, Max Planck Institute, Strathclyde University
Visiting PhD Researcher
Aug. 2019 – Sep. 2019
Corbion – Gorinchem, Netherlands
- R&D project: the exploration of new materials and product development
- Preparation of new solid phases: grinding and crystallization techniques
- Characterization of new multicomponent systems: DSC, Raman and XRPD
- Construction and study of the ternary phase diagram
- Proposal of strategies to scale-up and to promote the research results
- Writing experimental protocols in an electronic laboratory notebook
- Patent possibility currently under study
Visiting PhD researcher
May 2018 – Jun. 2018
Max Planck Institute for Dynamics of Complex Technical Systems – Magdeburg, Germany
- Kinetic studies: Crystal16
- Polymorph screening: DSC, FTIR, Raman, hot stage microscopy
- Chiral resolution by preferential crystallization
- Writing scientific reports
Visiting PhD researcher
Aug. 2017 – Sep. 2017
University of Strathclyde, Institute of Pharmacy and Biomedical Sciences – Glasgow, United Kingdom
- Study of the kinetic behaviour of several compounds in different solvents: Crystal16
- Structural analysis: single-crystal X-ray diffraction
- Writing scientific reports
Master internship
Mar. 2016 – Jul. 2016
Rennes Institute of Chemical Sciences, OMC Group – Rennes, France
- Multi-step organic synthesis of supramolecular complexes
- Purification and separation on a silica gel column
- Characterization methods: TLC coupled to the MALDI-TOF mass spectrometry and NMR spectroscopy
Research Intern
Oct. 2014 – Dec. 2014
Environmental Core Laboratory, American University of Beirut – Beirut, Lebanon
- Determination of physical, chemical, and microbiological content in drinking water, wastewater, soil, compost, and food
- Analysing the components of organic and inorganic compounds using HPLC
- Harfouche L. C., Couvrat N., Sanselme M., Cartigny Y., Brandel C., Petit S., Coquerel G. Discovery of New Proxyphylline Based Chiral Cocrystals: Solid State Landscape and Dehydration Mechanism. Crystal Growth and Design, 20 (6), 2020, 3842-3850.
- Harfouche L. C., Cartigny Y., Brandel C., Petit S., Coquerel G. (2020). Resolution by Preferential Crystallization of Proxyphylline by using its Salicylic Acid Monohydrate Co-crystal. Chemical Engineering & Technology, 43 (6), 2020, 1093-1098.
- Harfouche L. C., Cartigny Y., Brandel C., ter Horst J., Petit S., Coquerel G. Enabling Direct Preferential Crystallization in a Stable Racemic Compound System, Molecular Pharmaceutics, 16 (11), 2019, 4670-4676.
Certificate of Award: MARIE SKŁODOWSKA-CURIE Fellowship - European Commission - October 2020
• October 2019: Applying Cyclic Preferential Crystallization on Stable Racemic Systems. Oral presentation during a workshop at Friedrich–Alexander University Erlangen–Nürnberg, Erlangen, Germany.
• August 2019: Non-Classical Studies for Cyclic Preferential Crystallization of a Stable Racemic Compound. Oral presentation during the international conference on industrial crystallization BIWIC, VISTEC, Thailand.
• May 2019: Resolution of racemic compound via innovative ways. Oral presentation during the scientific event Cristal9, Nancy, France.
• May 2019: Chiral resolution of proxyphylline via its metastable conglomerate and its conglomerate co-crystal. Oral presentation during a workshop at SYNCOM company, Groningen, The Netherlands.
• September 2018: Polymorphism & Enantiomeric Resolution of Stable Racemic Systems. Oral presentation during a workshop at the University of Rouen, Rouen, France.
• September 2018: Implementation of preferential crystallization in unfavorable cases: Detection of metastable conglomerate. Poster presentation during the international conference on industrial crystallization BIWIC, Rouen, France.
• April 2018: Resolving of stable racemic systems by means of preferential crystallization. Oral presentation at the University of Manchester, Manchester, UK.
• November 2017: Concept of coupling kinetic data and thermodynamic aspects to resolve stable racemic systems by means of preferential crystallization. Oral presentation during a workshop held at TeraCrystal company, Cluj Napoca, Romania.
• July 2017: Chiral Resolution of Pharmaceutical Racemic Compounds: Implementation of Preferential Crystallization in Unfavorable Cases. Poster session presented at Radboud University, Nijmegen, The Netherlands.
