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Lina HARFOUCHE
Postdoctoral Researcher

27 y.o.

06 11 36 40 49
lina.harfouche@etu.univ-rouen.fr

Laboratoire SMS
Place Emile Blondel
76821 Mont-Saint-Aignan CEDEX
France

 

PhD Thesis
Ph.D.: Materials Chemistry

Jan. 2017 - May 2020

University of Rouen NormandyRouen, France

  • Marie Skłodowska-Curie Innovative Training Network Fellow
  • Completed professional development in:
  • Training and research in the field of chirality, synthesis, and crystallization
  • Training on transferable skills: project management, upward communication, intellectual property, public engagement, dissemination of results
Education
EdX, Inc. (online Learning Platform): Business Communication

Aug. 2020

University of British ColumbiaVancouver, Canada

EdX, Inc. (online Learning Platform): Business Foundations

Jun. 2020

University of British ColumbiaVancouver, Canada

Ph.D.: Materials Chemistry

May 2020

University of Rouen Normandy – Rouen, France

Master 2:  Physical Chemistry, Materials and Catalysis

Jul. 2016

Lebanese UniversityBeirut, Lebanon

Master 1: Environmental Chemistry

Jul. 2015

Lebanese UniversityBeirut, Lebanon

Master 1: Analytical Chemistry

Jul. 2014

Lebanese UniversityBeirut, Lebanon

Bachelor: General Chemistry

Jul. 2013

Lebanese University – Beirut, Lebanon

Work Experience
Postdoctoral Researcher

Sept. 2020 – Present

University of Rouen NormandyRouen, France

  • Crystallization kinetics: studying growth kinetics occurring during crystallization from solution
  • Characterization of materials: XRPD, DSC, TGA, Crystal16, SEM, solubility, and induction time
  • Probability Distributions of Induction Times
  • Usage of vibrational circular dichroism spectroscopy technique
PhD Researcher in Materials Science

Jan. 2017 – Mar. 2020

University of Rouen NormandyRouen, France

  • Crystallization of APIs: Screening and evaluation of polymorphs and cocrystals
  • Characterization techniques: NMR, XRPD, DSC, TGA, DVS, FTIR, Raman, Crystal16, hot stage and polarized microscopy, SEM, solubility and HPLC
  • Optimization of crystallization and chiral resolution processes
  • Solid-state landscape study and construction of phase diagrams
  • Characterization of solid-solid transition mechanisms and dehydration processes
  • Writing scientific articles and reports
  • Presentation of results in 9 international conferences, workshops, and summer schools
  • Collaboration with foreign institutions: Corbion, Max Planck Institute, Strathclyde University

Visiting PhD Researcher

Aug. 2019 – Sep. 2019

CorbionGorinchem, Netherlands

  • R&D project: the exploration of new materials and product development
  • Preparation of new solid phases: grinding and crystallization techniques
  • Characterization of new multicomponent systems: DSC, Raman and XRPD
  • Construction and study of the ternary phase diagram
  • Proposal of strategies to scale-up and to promote the research results
  • Writing experimental protocols in an electronic laboratory notebook
  • Patent possibility currently under study

Visiting PhD researcher

May 2018 – Jun. 2018

Max Planck Institute for Dynamics of Complex Technical SystemsMagdeburg, Germany

  • Kinetic studies: Crystal16
  • Polymorph screening: DSC, FTIR, Raman, hot stage microscopy
  • Chiral resolution by preferential crystallization
  • Writing scientific reports

Visiting PhD researcher

Aug. 2017 – Sep. 2017

University of Strathclyde, Institute of Pharmacy and Biomedical Sciences – Glasgow, United Kingdom

  • Study of the kinetic behaviour of several compounds in different solvents: Crystal16
  • Structural analysis: single-crystal X-ray diffraction
  • Writing scientific reports

Master internship

Mar. 2016 – Jul. 2016

Rennes Institute of Chemical Sciences, OMC GroupRennes, France

  • Multi-step organic synthesis of supramolecular complexes
  • Purification and separation on a silica gel column
  • Characterization methods: TLC coupled to the MALDI-TOF mass spectrometry and NMR spectroscopy

Research Intern

Oct. 2014 – Dec. 2014

Environmental Core Laboratory, American University of BeirutBeirut, Lebanon

  • Determination of physical, chemical, and microbiological content in drinking water, wastewater, soil, compost, and food
  • Analysing the components of organic and inorganic compounds using HPLC

           

Papers
  • Harfouche L. C., Couvrat N., Sanselme M., Cartigny Y., Brandel C., Petit S., Coquerel G. Discovery of New Proxyphylline Based Chiral Cocrystals: Solid State Landscape and Dehydration Mechanism. Crystal Growth and Design, 20 (6), 2020, 3842-3850.
  • Harfouche L. C., Cartigny Y., Brandel C., Petit S., Coquerel G. (2020). Resolution by Preferential Crystallization of Proxyphylline by using its Salicylic Acid Monohydrate Co-crystal. Chemical Engineering & Technology, 43 (6), 2020, 1093-1098.
  • Harfouche L. C., Cartigny Y., Brandel C., ter Horst J., Petit S., Coquerel G. Enabling Direct Preferential Crystallization in a Stable Racemic Compound System, Molecular Pharmaceutics, 16 (11), 2019, 4670-4676. 
Symposium Participation

• October 2019: Applying Cyclic Preferential Crystallization on Stable Racemic Systems. Oral presentation during a workshop at Friedrich–Alexander University Erlangen–Nürnberg, Erlangen, Germany.
• August 2019: Non-Classical Studies for Cyclic Preferential Crystallization of a Stable Racemic Compound. Oral presentation during the international conference on industrial crystallization BIWIC, VISTEC, Thailand.
• May 2019: Resolution of racemic compound via innovative ways. Oral presentation during the scientific event Cristal9, Nancy, France.
• May 2019: Chiral resolution of proxyphylline via its metastable conglomerate and its conglomerate co-crystal. Oral presentation during a workshop at SYNCOM company, Groningen, The Netherlands.
• September 2018: Polymorphism & Enantiomeric Resolution of Stable Racemic Systems. Oral presentation during a workshop at the University of Rouen, Rouen, France.
• September 2018: Implementation of preferential crystallization in unfavorable cases: Detection of metastable conglomerate. Poster presentation during the international conference on industrial crystallization BIWIC, Rouen, France.
• April 2018: Resolving of stable racemic systems by means of preferential crystallization. Oral presentation at the University of Manchester, Manchester, UK.
• November 2017: Concept of coupling kinetic data and thermodynamic aspects to resolve stable racemic systems by means of preferential crystallization. Oral presentation during a workshop held at TeraCrystal company, Cluj Napoca, Romania.
• July 2017: Chiral Resolution of Pharmaceutical Racemic Compounds: Implementation of Preferential Crystallization in Unfavorable Cases. Poster session presented at Radboud University, Nijmegen, The Netherlands.

Scientific Skills
Thermal Analysis (DSC – TG-DSC) – Implementation
Thermal Analysis (DSC – TG-DSC) – Interpretation
XRay Powder diffraction - user
Phase Diagram - Experimental Determination
Heterogeneous Equilibria
Microscopy (optical, electronic)
Chiral Resolution by Crystallization
Single Crystal X-ray Diffraction
Crystallography (structural description)
Solution Crystallization (polymorphism control, crystal engineering, salt, co-crystals)
Specific Crystallization Processes (Viedma Ripenning, Melt Crystallization, Sublimation, Preferential Enrichment…)
Organic Synthesis
Statistic treatment of data
Spectroscopy (Raman, Infra-rouge, UV-vis, fluorescence)
NMR spectroscopy
Solid-vapour equilibria (DVS)
Solid-state characterization (polymorphism, solvates, cocrystals, solid-solid transition)