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Mr. Benjamin SCHAMME
PhD Student

26 y. o.

02 35 52 24 32
benjamin.schamme1@univ-rouen.fr

Laboratoire SMS
Place Emile Blondel
76821 Mont-Saint-Aignan CEDEX
France

 

PhD Thesis

Molecular Mobility, Crystallization Mechanisms and Physical Stability of Amorphous Pharmaceutical Compounds: Impact of Preparation Pathways, Dr. Valérie Dupray, Region grant, 02nd December 2016.

Education

Double Master Franco-American in Mechanical and Materials Engineering, University of Lincoln-Nebraska, United States

Bachelor in Materials Science, University of Rouen Normandie, France

Work Experience

Assistant in the Chemistry department, University of Rouen Normandie

(Experimental classes in inorganic chemistry to Bachelor level students)

Papers

Schammé, B.; Couvrat, N.; Malpeli, P.; Delbreilh, L.; Dupray, V.; Dargent, E.; Coquerel, G. Crystallization kinetics and molecular mobility of an amorphous active pharmaceutical ingredient: a case study with Biclotymol. Int. J. Pharm. 2015, 490, 248–257. (DOI:10.1016/j.ijpharm.2015.05.036).

Schammé, B.; Couvrat, N.; Malpeli, P.; Dudognon, E.; Delbreilh, L.; Dupray, V.; Dargent, E.; Coquerel, G. Transformation of an active pharmaceutical ingredient upon high-energy milling: A process-induced disorder in Biclotymol. Int. J. Pharm. 2016, 499, 67–73. (DOI:10.1016/j.ijpharm.2015.12.032).

Schammé, B.; Mignot, M.; Couvrat, N.; Tognetti, V.; Joubert, L.; Dupray, V.; Delbreilh, L.; Dargent, E.; Coquerel, G. Molecular Relaxations in Supercooled Liquid and Glassy States of Amorphous Quinidine: Dielectric Spectroscopy and Density Functional Theory Approaches. J. Phys. Chem. B, 2016, 120, 7579–7592. (DOI: 10.1021/acs.jpcb.6b04242).

Awards

Award of the best scientific presentation by the French Physics Society (6th PhD student Day of the doctoral school, June 11, 2015, Rouen)

Symposium Participation
Oral communications (as speaker)
 
 1) “On the molecular origin of a sub-Tg relaxation in an amorphous pharmaceutical: Density Functional Theory (DFT) approach”, B. Schammé, M. Mignot, V. Tognetti, L. Joubert, N. Couvrat, V. Dupray, L. Delbreilh, E. Dargent, G. Coquerel, European Symposium on Chemical Bonding, ESCB1, August 29 to September 2, 2016, Rouen (FRANCE)
 
2) “Processing of Solid Pharmaceuticals: Advantages and Drawbacks”, B. Schammé, N. Couvrat, V. Dupray, L. Delbreilh, E. Dargent, G. Coquerel, Journées Nord-Ouest Européennes des Jeunes Chercheurs, JNOEJC, June 9-10, 2016, Lille (FRANCE)
 
3) “Transformation of Active Pharmaceutical Ingredients Upon High-Energy Milling”, B. Schammé, E. Dudognon, N. Couvrat, V. Dupray, L. Delbreilh, E. Dargent, G. Coquerel, Cristal8, May 26-27, 2016, Rouen (FRANCE)
 
4) “Transformation of Solid Pharmaceuticals: How to enhance biodisponibility?”, B. Schammé, N. Couvrat, V. Dupray, L. Delbreilh, E. Dargent, G. Coquerel, 6th PhD student Day of the doctoral school, June 11, 2015, Rouen (FRANCE)
 

5) “Role of Molecular Mobility on Physical Stability: Case study of two Amorphous Pharmaceuticals in the Supercooled and Glassy States”, B. Schammé, N. Couvrat, V. Dupray, L. Delbreilh, E. Dargent, G. Coquerel, 23rd World Forum on Advanced Materials, PolyChar 23, May 11-15, 2015, Lincoln, Nebraska (UNITED-STATES)

6) “Molecular Mobility, Crystallization kinetics and Physical stability of Amorphous Biclotymol”, B. Schammé, L. Delbreilh, N. Couvrat, V. Dupray, G. Coquerel, Condensed Matter, CMD25, August 24-29, 2014, Paris (FRANCE)
Scientific Skills
Thermal Analysis (DSC – TG-DSC) – Implementation
Thermal Analysis (DSC – TG-DSC) – Interpretation
XRay Powder diffraction - user
Molecular Modeling (indicate level of theory)
Microscopy (optical, electronic)
Spectroscopy (Raman, Infra-rouge, UV-vis, fluorescence)
Amorphous state characterization (thermal analysis / Broadband Dielectric Spectroscopy)
Crystallization kinetics of amorphous solids (DSC, TM-DSC,...)