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Mrs. Mélanie MIGNOT
PhD Student

26 y.o.

+33 2 35 52 24 32
melanie.mignot1@univ-rouen.fr

Laboratoire SMS
Place Emile Blondel
76821 Mont-Saint-Aignan CEDEX
France

 

PhD Thesis

Elaboration of original stationary phases for high-performance liquid chromatography: Synthesis, characterization, and evaluation of the chromatographic properties, Dr. HDR PEULON AGASSE Valérie and Prof. CARDINAEL Pascal, French ministerial research grant, 2016/12/01

Education

Master in Analytical Chemistry, University of Rouen Normandie, France-With honors, Major

Bachelor in Chemistry, University of Rouen Normandie, France

Work Experience
  • 2016-2017 : Full-time assistant, Chemical & Physical departments, IUT of Rouen (196h)

(Courses in chemometrics, tutorial classes in chemistry, experimental classes in chemistry, in chromatography, in spectroscopy and inorganic chemistry)

  • 2015-2016 : Assistant in the Chemistry department, University of Rouen Normandie (64h)

(Courses and experimental classes in spectroscopy, analytical chemistry, and environmental chemistry to Bachelor level students)

 

Industrial collaboration, Interchim, Montluçon, FRANCE

 → Elaboration of stationary phases based on core-shell particles in HPLC

  • Industrial collaboration, PerkinElmer, Courtaboeuf, FRANCE

→  Redaction of an application note: HPLC-core-shell-chemometrics

  • Academic collaboration (internship), LCAP, University of Geneva, SWITZERLAND

→ Evaluation of the kinetic performances of some hand-made columns in Hilic mode with

the Kinetic plots theory-Supervisors: Dr. D. Guillarme and Prof. J.L. Veuthey

  • Academic collaboration (internship), LCO, University of Brussels, BELGIUM

→  Synthesis and characterization of new calix[6]arenes containing an acid group for

functionalization on core-shell amino-functionalized silica particles-Supervisor: Prof. I. Jabin

  • Academic collaboration, analysis & modeling unit, University of Rouen, FRANCE

→  Modeling of the 3D structure of new stationary phases and rationalization of the

retention process towards aromatic compounds-Supervisor: Dr. Vincent Tognetti

→ Structural characterization of modified silica particles by CP/MAS 29Si, 13C, 1H NMR- Supervisor: Dr. Muriel Sebban

Papers
  • M. Mignot, A. Tchapla, O. Mercier, N. Couvrat, S. Tisse, P. Cardinael, V. Peulon-Agasse Chromatographia 77 (2014) 1577-1588
  • M. Mignot, M. Sebban, A. Tchapla, O. Mercier, P. Cardinael, V. Peulon-Agasse, J. Chromatogr., A, 1419 (2015) 45-57
  • M. Mignot, A. Périat, V. Peulon-Agasse, P. Cardinael, J.L. Veuthey, D. Guillarme, J. Sep. Sci. 39 (2016) 1611–1618
  • A. Burel, S.J.T. Brugman, M. Mignot, Y. Cartigny, S. Tisse, N. Couvrat, V. Peulon‐Agasse, P. Cardinael, G. Coquerel, Chem. Eng. Technol. 39 (2016) 1317-1325
  • B. Schammé, M. Mignot, N. Couvrat, V. Tognetti, L. Joubert, V. Dupray, L. Delbreilh, É. Dargent, G. Coquerel, J. Phys. Chem. B 120 (2016), 7579-7592
Awards
  • Finalist for Consideration of the 2016 Csaba Horváth Young Scientist Award, HPLC 2016, San Francisco, 2016, June, 19-24th
  • Award of the best scientific presentation, Journées Nord-Ouest Européennes des Jeunes Chercheurs, Rouen, 2015, May, 11-12th
  • Award of the best scientific presentation, VIIèmes journées scientifiques du Club Jeunes de l'AFSEP, Paris, 2014, July, 7-8th
Symposium Participation

Most representative oral communications (as speaker):

  • “Using DFT approaches to investigate the enhanced aromatic selectivity of new antracenyl polar embedded stationary phases for Liquid Chromatography”, Mignot, M.; Schammé, B.; Tognetti, V.; Joubert, L.; Tchapla, A.; Mercier, O.; Cardinael, P.; Peulon-Agasse, V. ESCB1, Rouen, August 29th-September 2nd (FRANCE)
  • “Same core-shell silica batch, same microwave grafting procedure leading to various C18 stationary phases? Insight in thermal pretreatments”, Mignot, M.; Sebban, M.; Tchapla, A.; Mercier, O.; Cardinael, P.; Peulon-Agasse, V. HPLC 2016, San Francisco, 2016, June, 19-24th (UNITED STATES)
  • “New insights for the development of polar-embedded aromatic stationary phases” Mignot, M.; Schammé, B.; Tognetti, V.; Joubert, L.; Tchapla, A.; Mercier, O.; Cardinael, P.; Peulon-Agasse, V.  Journées Nord-Ouest Européennes des Jeunes Chercheurs, Lille, 2016, June, 9-10th (FRANCE)
  •  “Microwave preparation, characterization, and evaluation of a new polar-embedded aromatic core-shell stationary phase for high-performance liquid chromatography” Mignot, M.; Schammé, B.; Tognetti, V.; Joubert, L.; Tchapla, A.; Mercier, O.; Cardinael, P.; Peulon-Agasse, V. Euroanalysis, Bordeaux, 2015, September, 6-10th (FRANCE)
  • “How thermal treatments could impact C18 stationary phases made of core-shell particles?”

Mignot, M.; Sebban, M.; Tchapla, A.; Mercier, O.; Cardinael, P.; Peulon-Agasse, V. Journées Nord-Ouest Européennes des Jeunes Chercheurs, Rouen, 2015, May, 11-12th (FRANCE)

  • « Dans quelle mesure les prétraitements thermiques impactent-ils les phases stationnaires C18 à base de particules de silice partiellement poreuses? », Mignot, M.; Sebban, M.; Tchapla, A.; Mercier, O.; Cardinael, P.; Peulon-Agasse, V. 11ème congrès francophone de l’AFSEP sur les Sciences séparatives et les couplages, Versailles, 2015, March, 31th-April, 2nd (FRANCE)

Most representative poster communications (as presenter):

  • “New polar-embedded aromatic core-shell stationary phases for high-performance liquid chromatography”, Mignot, M.; Schammé, B.; Tognetti, V.; Joubert, L.; Tchapla, A.; Mercier, O.; Cardinael, P.; Peulon-Agasse, V. HPLC 2016, San Francisco, 2016, June, 19-24th (UNITED STATES)
  • 1) “Microwave preparation, characterization, and evaluation of a new polar-embedded aromatic core-shell stationary phase for high-performance liquid chromatography”, Mignot, M.; Schammé, B.; Tognetti, V.; Joubert, L.; Tchapla, A.; Mercier, O.; Cardinael, P.; Peulon-Agasse, V.

2)“Could the same core-shell silica batch functionalized with the same microwave procedure lead to various C18 stationary phases? Insight in thermal pretreatments” Mignot, M.; Sebban, M.; Tchapla, A.; Mercier, O.; Cardinael, P.; Peulon-Agasse, V. HPLC 2015, Geneva, 2015, June, 21-25th (SWITZERLAND)

  • « Diviser par 10 le temps de fonctionnalisation de particules de silice partiellement poreuses ? Micro-ondes versus chauffage à reflux », Mignot, M.; Tchapla, A.; Mercier, O.; Couvrat, N.; Tisse, S.; Cardinael, P.; Peulon-Agasse, V. 11ème congrès francophone de l’AFSEP sur les Sciences séparatives et les couplages, Versailles, 2015, March, 31th-April, 2nd (FRANCE)
  • 1) “Core-shell silica particles: Functionalization, characterization and evaluation of the stationary phases. Around the microwave heating silica grafting”, Mignot, M.; Tchapla, A.; Mercier, O.; Couvrat, N.; Tisse, S.; Cardinael, P.; Peulon-Agasse, V.

2) “Core-shell silica particles: Octadecyl silica particles by hydrosilylation and organosilanization”, Mignot, M.; Tchapla, A.; Mercier, O.; Couvrat, N.; Tisse, S.; Cardinael, P.; Peulon-Agasse, V. 30th International Symposium on Chromatography (ISC 2014), Salzburg, 2014, September, 14-18th (AUSTRIA)

Scientific Skills
Molecular Modeling (indicate level of theory)
Microscopy (optical, electronic)
Organic Synthesis assisted by microwaves
Conception of stationary phases for HPLC
Development of chromatographic methods for HPLC
Development of chromatographic methods coupled with mass spectrometry
Development of quantification methods
Statistic treatment of data
Filling chromatographic columns for HPLC
Spectroscopy (Raman, Infra-rouge, UV-vis, fluorescence)
NMR spectroscopy